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Express the difference from the group mean image Medication effect measurement software using the VBM method TRI/3D-BON-FCS-VBM This software uses VBM (Voxel Based Morphometry) method is used to visualize the difference in local physical property values between the experimental group and the control group to express the morphological characteristics of the experimental group. Local effect of drug effect can be measured when used for evaluation of drug effect is. Since the average value image of the experimental group is obtained by averaging the images, the individual differences are averaged and the characteristics of the experimental group are emphasized. |
 Application of VBM to bone analysis Lesion measurement of proximal femoral cortical bone 1.Mean value image creation  The case image (1) is transformed into the reference image (2) with the same anatomical parts matched. Create an average value image (3) by averaging physical property values ??such as density at each point 2. Measurement of medication effect Group comparison (1) Transform each of the experimental group and the control group into an average value image (2) Perform a significant difference test for each pixel on the average value image for the two groups. ① Average value for each group ② t-value image ③ p-value image 3. Gap from case mean Calculate the z-value for the mean value image of the case for each point on the image z-value = (case valueーAverage value） / σ 
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